Hexarelin is a Growth Hormone Releasing Peptide (GHRP). These are a group of synthetic compounds that mimic the effects of ghrelin, a gastrointestinal hormone involved in the regulation of food intake, body composition, and glucose metabolism. Like other GHRPs, hexarelin is an agonist of the growth hormone secretagogue receptor la (GHSRIa). It acts on hypothalamic and pituitary sites to stimulate the release of growth hormone. Hexarelin is a particularly potent member of the GHRP family, capable of substantial increases in serum GH and IGF-1. Compared to its predecessor GHRP-6, hexarelin is significantly more effective at elevating growth hormone, and displays a lower propensity for side effects. This drug is often used in the fitness community for fat loss and muscle gain, or as part of an anti-aging program. Hexarelin is a growth hormone similar to GHRP-6, however, it has been shown to be much stronger producing a larger increase in naturally produced growth hormone. Some data suggest it may be the strongest synthetic growth hormone releasing hormone on the market.
10mg Hexarelin (VIAL)
Hexarelin is primarily a growth hormone stimulating drug. However, like many GHRPs, its effect is not entirely selective. It does have some spillover effect onto other pituitary hormones. Most notably, hexarelin has been shown to also slightly increase ACTH (adrenocorticotropic hormone), cortisol, and prolactin levels. In each case, the intensity appears to be dose dependent. During studies with hexarelin, the drug did not cause a significant issue with regard to side effects, however. While these hormones were elevated during administration, they remained within the normal range in most cases. Hexarelin is also noted for increasing appetite. Anecdotally, however, this effect is less pronounced than it is with many of the other GHRPs.
Hexarelin has been studied for its potential cardioprotective effects. This may be in part mediated by its binding to both GHSRIa and CD36 receptors in tissues of the cardiovascular system. The latter affinity is not noted in ghrelin, and thus is unique to certain synthetic growth hormone releasing peptides. Hexarelin has been studied in several human clinical trials for this. These investigations found the drug to be well tolerated, and among other things, to increase cardiac output and left ventricular ejection fraction. Research suggests it may hold therapeutic potential with cardiovascular diseases such as cardiac fibrosis, ischemic heart disease, cardiac dysfunction, and atherosclerosis. More research will be needed before hexarelin can be widely adopted for such application.
Hexarelin is comprised of a chain of amino acids that cause the release of growth hormones into the body. Hexarelin causes significantly stronger increase in growth hormone compared to GHRP-6.
Hexarelin also one of the faster acting growth hormone products on the market, causing growth hormone levels increase as quickly as in four weeks. However, use past the sixteen week mark has been shown to produce little to no results. Therefore, an ideal Hexarelin cycle falls in the 8-12 week range with minimum of 4-6 weeks of no use between cycles.
Common side effects to hexarelin therapy include flushing, sweating, sleepiness, reduced REM sleep, increased Gl motility, and increased appetite. Also frequently reported are adverse effects typically associated with other types of growth hormone therapy, such as water retention (edema), joint pain (arthralgias), carpal tunnel syndrome, and numbness or tingling in the extremities. Note that the incidence of side effects tends to be lower with GHRP therapy as compared to traditional hGH. This is because GH/IGF-1 release is subject to endogenous synthesis, and as such the drug is less amenable to overdosing.
The subcutaneous administration of this drug may cause redness, itching, pain, or lumps at the site of injection. Injection site redness and discomfort is sometimes reported with intramuscular injection as well.
Hexarelin may reduce insulin sensitivity and raise blood sugar levels. This may occur in individuals without preexisting diabetes or impaired glucose tolerance.
Being one of the most powerful growth hormone releasing hormones on the market, Hexarelin is most beneficial to the performance athlete.
The off-season athlete should find increases in mass and strength, increased recovery and an ability to maintain lower levels of body fat. Additionally, the user will find his anabolic steroid cycle to be far more effective when using Hexarelin.
For the cutting athlete, the enhanced metabolism and healing properties are the most beneficial factors. Data has shown Hexarelin is one of the most beneficial growth hormone products in this regard.
Even though Hexarelin is not a suitable long-term option due to the short-lived use that seems to exist, but it’s recovery type benefits are still hard to ignore. Such benefits include:
- Joint healing
- Strengthening of the neural system
- Muscle fiber repair (ideal for injuries)
- Direct increase of bone density
- Heart protection
Hexarelin is administered via a subcutaneous injection. It comes in dry powder form to be mixed with bacteriostatic water. 200mcg per day appears to be the best dose for most in terms of benefits, although some may go as high as 400mcg per day. Most data shows benefits of 200mcg per day are not exceeded with higher doses of Hexarelin.
Due to the inactivity that will occur in time, 16 weeks of use max is the general recommendation with a minimum of 4 weeks of no use before starting again. Most users will find 8-12 weeks to be the most effective and beneficial time frame.
When used for physique- or performance-enhancing purposes, hexarelin is usually administered at a dosage of 0.05 to 0.2 mg (50-200 meg) per injection. This may be given 1 -2 times daily. If single episode dosing is preferred, this is taken before sleep. Day dose (if used) is taken on an empty stomach, 30-60 minutes before a meal. This is to preserve optimal GH release, as elevated plasma fatty acids and/or glucose may blunt the GH elevating effects of GHRPs. Total daily dosage generally does not exceed 400 meg.
It is common to taper up the dosage, beginning with only 50 meg per injection. This may be increased by 50 meg every several days, until a stable peak dosage is reached.
The efficacy of doses above 200 meg remains unclear. In studies giving hexarelin via IV infusion, the drug seemed to approach its maximum effect at about 2 meg/kg of bodyweight. This dose was also only incrementally better than 1 meg/kg, suggesting the point of maximum cost effectiveness is somewhere between 1-2 meg/kg. This would equate to an individual dosage of 100-200 meg for a person of 220 lbs. So no more than 400 meg per day seems reasonable if giving the drug on two instances, and no more than 200 meg with single episode dosing. Significantly more than this might be wasteful, and possibly increase the incidence of side effects.
The body becomes desensitized to the GH-elevating effects of Hexarelin overtime. For this reason, cycles are usually limited to 4 weeks in length. This time frame was chosen out of an abundance of caution. One study that examined desensitization found it does occur sometime after 4 weeks of use, and before 16 weeks (other time points were not examined). It is quite possible that longer cycles can be used without noticing significant downregulation.
Some people alternately opt to use hexarelin in long cycles, but do so on an intermittent schedule. This may be once every 2nd or 3rd day instead of daily. Hexarelin has not been subject to extensive study in humans. As such, a full understanding of the phenomenon of desensitization, and an optimal intake schedule, are lacking.
After each cycle, a minimum of 4 weeks is taken off of the drug. This period of time has been shown to reverse desensitization to hexarelin's GH-elevating effects.
Hexarelin side effects
The side effects of Hexarelin do not include those of a direct estrogenic nature. Water retention is possible yet it can usually be corrected through a diet, exercise or dosing adjustments. Hexarelin does not aromatize, but it can promote gynecomastia.
The side effects of Hexarelin do not include any of an androgenic nature. Acne and hair loss are not possible with this peptide. Virilization symptoms cannot occur in women due to this peptide.
Cholesterol and blood pressure should not be negatively affected by the use of Hexarelin. Data has shown that the peptide may in fact improve heart health.
Hexarelin is not liver toxic.
Hexarelin will not suppress natural testosterone production. The side effects of Hexarelin may include elevated levels of cortisol. Individuals with elevated levels of cortisol may suffer from insomnia or restless sleep, experience fat gain despite proper diet and exercise, and a weaker immune system. Depression, a decreased libido and increased anxiety may also be signs of elevated cortisol levels.